Molecular weight (DA)
47+76kD
Immunogen
The antiserum was produced against synthesized peptide derived from human C1S. AA range:388-437
Specificity
Cleaved-C1s HC (R437) Polyclonal Antibody detects endogenous levels of fragment of activated C1s HC protein resulting from cleavage adjacent to R437.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009],
Function
catalytic activity:Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase.,disease:Defects in C1S are the cause of selective C1s deficiency [MIM:120580]; that is associated with early onset multiple autoimmune diseases.,enzyme regulation:Inhibited by SERPING1.,function:C1s B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.,online information:C1S mutation db,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase S1 dom
Protein name
Complement C1s subcomponent
Other name
C1S; Complement C1s subcomponent; C1 esterase; Complement component 1 subcomponent s
Fields
>>Complement and coagulation cascades;>>Pertussis;>>Staphylococcus aureus infection;>>Coronavirus disease - COVID-19;>>Systemic lupus erythematosus
Human protein sequence Database
P09871
Mouse protein sequence database
Rat protein sequence database
Cellular localization
extracellular region,extracellular exosome,blood microparticle,
Tissue expression
Liver,Peripheral blood leukocyte,Plasma,PNS,
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