Immunogen
Purified recombinant fragment of human CD14 expressed in E. Coli.
Specificity
CD14 Monoclonal Antibody detects endogenous levels of CD14 protein.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Dilution rate
IHC: 1/200 - 1/1000. Flow cytometry: 1/200 - 1/400. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010],
Function
function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
Protein name
Monocyte differentiation antigen CD14
Other name
CD14; Monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein; CD antigen CD14
Fields
>>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Phagosome;>>Toll-like receptor signaling pathway;>>Hematopoietic cell lineage;>>Alcoholic liver disease;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Amoebiasis;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Lipid and atherosclerosis
Human protein sequence Database
P08571
Mouse protein sequence database
P10810
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Membrane raft . Golgi apparatus . Secreted forms may arise by cleavage of the GPI anchor. .
Tissue expression
Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
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