Immunogen
The antiserum was produced against synthesized peptide derived from human SH2D1B. AA range:71-120
Specificity
EAT-2 Polyclonal Antibody detects endogenous levels of EAT-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008],
Function
function:Plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.,similarity:Contains 1 SH2 domain.,subunit:Binds to the phosphorylated receptors CD84, CD150, CD229 and CD244. Does not bind to non-phosphorylated CD150.,
Protein name
SH2 domain-containing protein 1B
Other name
SH2D1B; EAT2; SH2 domain-containing protein 1B; EWS/FLI1-activated transcript 2; EAT-2
Fields
>>Natural killer cell mediated cytotoxicity
Human protein sequence Database
O14796
Mouse protein sequence database
O35324
Rat protein sequence database
Cellular localization
intracellular,cytosol,
Tissue expression
Leukocyte,Lung,Spleen,
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