Immunogen
Synthesized peptide derived from the C-terminal region of human FDC-SP. AA range: 26-75
Specificity
FDC-SP Polyclonal Antibody detects endogenous levels of FDC-SP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011],
Function
function:Can bind to the surface of B-lymphoma cells, but not T-lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.,tissue specificity:Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.,
Protein name
Follicular dendritic cell secreted peptide
Other name
FDCSP; C4orf7; Follicular dendritic cell secreted peptide; FDC secreted protein; FDC-SP
Human protein sequence Database
Q8NFU4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon.
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