Molecular weight (DA)
26kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TSPAN8. AA range:96-145
Specificity
Tetraspanin-8 Polyclonal Antibody detects endogenous levels of Tetraspanin-8 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008],
Function
similarity:Belongs to the tetraspanin (TM4SF) family.,tissue specificity:Gastric, colon, rectal, and pancreatic carcinomas.,
Protein name
Tetraspanin-8
Abbreviation
Tetraspanin-8
Other name
TSPAN8; TM4SF3; Tetraspanin-8; Tspan-8; Transmembrane 4 superfamily member 3; Tumor-associated antigen CO-029
Human protein sequence Database
P19075
Mouse protein sequence database
Q8R3G9
Rat protein sequence database
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Gastric, colon, rectal, and pancreatic carcinomas.
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