Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from the C-terminal region of human TXA synthase.
Specificity
TXA synthase Polyclonal Antibody detects endogenous levels of TXA synthase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function
catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromboxa-5,13-dienoate.,cofactor:Heme group.,disease:Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.,disease:Defects in TBXAS1 are the cause of thromboxane synthetase deficiency [MIM:274180]. It is characterized by hemorrhagic diathesis.,online information:CYP5A1 alleles,similarity:Belongs to the cytochrome P450 family.,subunit:Monomer.,tissue specificity:Platelets, lung, kidney, spleen, macrophages and lu
Protein name
Thromboxane-A synthase
Abbreviation
TXA synthase
Other name
TBXAS1; CYP5; CYP5A1; Thromboxane-A synthase; TXA synthase; TXS; Cytochrome P450 5A1
Fields
>>Arachidonic acid metabolism;>>Metabolic pathways;>>Platelet activation
Human protein sequence Database
P24557
Mouse protein sequence database
P36423
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.
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