Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from the Internal region of human Hepassocin.
Specificity
Hepassocin Polyclonal Antibody detects endogenous levels of Hepassocin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
fibrinogen like 1(FGL1) Homo sapiens Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008],
Function
function:Has hepatocyte mitogenic activity.,similarity:Contains 1 fibrinogen C-terminal domain.,subunit:Homodimer.,tissue specificity:Liver specific.,
Protein name
Fibrinogen-like protein 1
Other name
FGL1; HFREP1; Fibrinogen-like protein 1; HP-041; Hepassocin; Hepatocyte-derived fibrinogen-related protein 1; HFREP-1; Liver fibrinogen-related protein 1; LFIRE-1
Human protein sequence Database
Q08830
Mouse protein sequence database
Q71KU9
Rat protein sequence database
Q5M8C6
Cellular localization
Secreted . Secreted in the blood plasma. .
Tissue expression
Under normal conditions, liver-specific.
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