Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CEACAM3/CEACAM6. AA range:31-80
Specificity
CD66c/d Polyclonal Antibody detects endogenous levels of CD66c/d protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013],
Function
caution:This is not the ortholog of rat CEACAM3.,domain:The cytosolic domain is involved in S100A9 interaction.,function:Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.,PTM:Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.,similarity:Belongs to the immunoglobulin superfamily. CEA family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation.,tissue specificity:CGM1a, the pred
Gene Name
CEACAM3/CEACAM6
Protein name
Carcinoembryonic antigen-related cell adhesion molecule 3/Carcinoembryonic antigen-related cell adhesion molecule 6
Other name
CEACAM3; CD66D; CGM1; Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen CGM1; CD66d; CEACAM6; NCA; Carcinoembryonic antigen-related cell adhesion molecule 6; Non-specific crossreacting antigen; Normal cross-reacting antigen; CD66c
Human protein sequence Database
P40198/P40199
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane; Single-pass type I membrane protein.
Tissue expression
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
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