Immunogen
Synthetic peptide from human protein at AA range: 150-193
Specificity
The antibody detects endogenous CD70
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008],
Function
function:Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,
Gene Name
CD70 CD27L CD27LG TNFSF7
Protein name
CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)
Other name
CD70 antigen (CD27 ligand;CD27-L;Tumor necrosis factor ligand superfamily member 7;CD antigen CD70)
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
P32970
Mouse protein sequence database
O55237
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type II membrane protein .
Tissue expression
B-cell,Kidney,
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