Molecular weight (DA)
57kD
Immunogen
Purified recombinant human PP5 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of PP5 and does not cross-react with related protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011],
Function
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,function:May play a role in the regulation of RNA biogenesis and/or mitosis. In vitro, dephosphorylates serine residues of skeletal muscle phosphorylase and histone H1.,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.,similarity:Contains 3 TPR repeats.,subcellular location:Predominantly nuclear. But also present in the cytoplasm.,subunit:Interacts with CDC16 and CDC27.,tissue specificity:Ubiquitous.,
Other name
FLJ36922;FLJ55954;OTTHUMP00000165834;PP-T;PP5;PPP5;PPP5_HUMAN;PPP5C;PPT;Protein phosphatase 5, catalytic subunit;Protein phosphatase T;Serine/threonine protein phosphatase 5;Serine/threonine-protein phosphatase 5.
Fields
>>MAPK signaling pathway
Human protein sequence Database
P53041
Mouse protein sequence database
Q60676
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Cell membrane . Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). .
Tissue expression
Ubiquitous.
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