Molecular weight (DA)
80kD
Immunogen
Purified recombinant human GRK2 protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of GRK2 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.,online information:Beta adrenergic receptor kinase entry,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,subunit:Interacts with GIT1 (By similarity). Interacts with, and phosphorylates chemokine-stimulated CCR5.,tissue specificity:Expressed in peripheral blood leukocytes.,
Other name
ADRBK 1;ADRBK1;Adrenergic beta receptor kinase 1;Adrenergic beta receptor kinase 1; ARBK1_HUMAN;BARK 1;BARK;BARK1;Beta adrenergic receptor kinase 1;Beta ARK 1;Beta ARK1; Beta-adrenergic receptor kinase 1;Beta-ARK-1;FLJ16718;G Protein Coupled Receptor Kinase 2;G protein dependent receptor kinase 2;G-protein coupled receptor kinase 2;GRK 2;GRK2.
Fields
>>Chemokine signaling pathway;>>Endocytosis;>>Hedgehog signaling pathway;>>Glutamatergic synapse;>>Olfactory transduction;>>Morphine addiction
Human protein sequence Database
P25098
Mouse protein sequence database
Q99MK8
Rat protein sequence database
Cellular localization
Cytoplasm . Cell membrane . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse .
Tissue expression
Expressed in peripheral blood leukocytes.
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