Molecular weight (DA)
134kD
Immunogen
Synthesized phosho peptide around human Tyk2 (Tyr1054 and 1055)
Specificity
This antibody detects endogenous levels of Human Tyk2 (phospho-Tyr1054 or 1055)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
tyrosine kinase 2(TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also called autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. The syndrome consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.,online information:TYK2 mutation db,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Conta
Protein name
Tyk2 (Tyr1054/1055)
Other name
Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2)
Fields
>>Necroptosis;>>Osteoclast differentiation;>>NOD-like receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Toxoplasmosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Influenza A;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19
Human protein sequence Database
P29597
Mouse protein sequence database
Q9R117
Rat protein sequence database
Cellular localization
nucleus,cytoplasm,cytosol,cytoskeleton,membrane,extrinsic component of cytoplasmic side of plasma membrane,extracellular exosome,
Tissue expression
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
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