Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ADK. AA range:1-50
Specificity
ADK Polyclonal Antibody detects endogenous levels of ADK protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
Function
catalytic activity:ATP + adenosine = ADP + AMP.,cofactor:Binds 3 magnesium ions per subunit.,function:ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.,pathway:Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.,similarity:Belongs to the carbohydrate kinase pfkB family.,subunit:Monomer.,tissue specificity:Widely expressed. Highest level in placenta, liver, muscle and kidney.,
Protein name
Adenosine kinase
Other name
ADK; Adenosine kinase; AK; Adenosine 5'-phosphotransferase
Fields
>>Purine metabolism;>>Metabolic pathways;>>Nucleotide metabolism
Human protein sequence Database
P55263
Mouse protein sequence database
P55264
Rat protein sequence database
Q64640
Cellular localization
[Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
Tissue expression
Widely expressed. Highest level in placenta, liver, muscle and kidney.
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