Molecular weight (DA)
30kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CKI-alpha1/L. AA range:141-190
Specificity
Casein Kinase I α1/1L Polyclonal Antibody detects endogenous levels of Casein Kinase I α1/1L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,
Gene Name
CSNK1A1/CSNK1A1L
Protein name
Casein kinase I isoform alpha/Casein kinase I isoform alpha-like
Abbreviation
Casein Kinase I α1/1L
Other name
CSNK1A1L; Casein kinase I isoform alpha-like; CKI-alpha-like; CK1; CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1
Fields
>>Wnt signaling pathway;>>Hedgehog signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Human papillomavirus infection;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer
Human gene ID
122011/1452
Human protein sequence Database
Q8N752/P48729
Mouse protein sequence database
Rat protein sequence database
P97633
Cellular localization
Cytoplasm .
Tissue expression
Testis,
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