Molecular weight (DA)
87kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CGK 2. AA range:391-440
Specificity
cGKII Polyclonal Antibody detects endogenous levels of cGKII protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,
Protein name
cGMP-dependent protein kinase 2
Other name
PRKG2; PRKGR2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII
Fields
>>cGMP-PKG signaling pathway;>>Gap junction;>>Platelet activation;>>Circadian entrainment;>>Thermogenesis;>>Long-term depression;>>Olfactory transduction;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Salivary secretion
Human protein sequence Database
Q13237
Mouse protein sequence database
Q61410
Rat protein sequence database
Q64595
Cellular localization
Apical cell membrane ; Lipid-anchor .
Tissue expression
Highly concentrated in brain, lung and intestinal mucosa.
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