Molecular weight (DA)
59kD
Immunogen
The antiserum was produced against synthesized peptide derived from human DAK. AA range:91-140
Specificity
DHA Kinase Polyclonal Antibody detects endogenous levels of DHA Kinase protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + glycerone = ADP + glycerone phosphate.,catalytic activity:FAD = AMP + riboflavin cyclic-4',5'-phosphate.,cofactor:Magnesium.,cofactor:Manganese or cobalt; for FAD-AMP lyase activity.,enzyme regulation:Each activity is inhibited by the substrate(s) of the other.,function:Catalyzes both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate.,similarity:Belongs to the dihydroxyacetone kinase (DAK) family.,similarity:Contains 1 DAK1 (dihydroxyacetone kinase subunit 1) domain.,similarity:Contains 1 DAK2 (dihydroxyacetone kinase subunit 2) domain.,subunit:Homodimer.,
Protein name
Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase
Other name
DAK; Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase; cyclizing
Fields
>>Fructose and mannose metabolism;>>Glycerolipid metabolism;>>Metabolic pathways;>>Carbon metabolism;>>RIG-I-like receptor signaling pathway
Human protein sequence Database
Q3LXA3
Mouse protein sequence database
Q8VC30
Rat protein sequence database
Q4KLZ6
Cellular localization
nucleus,cytosol,extracellular exosome,
Tissue expression
Detected in erythrocytes (at protein level).
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