Molecular weight (DA)
95kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RASA3. AA range:247-296
Specificity
GAP1-InsP4 BP Polyclonal Antibody detects endogenous levels of GAP1-InsP4 BP protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Function
function:Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-GAP domain.,similarity:Contains 2 C2 domains.,
Protein name
Ras GTPase-activating protein 3
Abbreviation
GAP1-InsP4 BP
Other name
RASA3; Ras GTPase-activating protein 3; GAP1(IP4BP); Ins P4-binding protein
Fields
>>Ras signaling pathway
Human protein sequence Database
Q14644
Mouse protein sequence database
Q60790
Rat protein sequence database
Q9QYJ2
Cellular localization
Cell membrane.
Tissue expression
Blood,Brain,Peripheral blood,Platelet,Testis,
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