Molecular weight (DA)
65kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GRK6. AA range:10-59
Specificity
GRK 6 Polyclonal Antibody detects endogenous levels of GRK 6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors.,PTM:It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Widely expressed.,
Protein name
G protein-coupled receptor kinase 6
Other name
GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6
Fields
>>Chemokine signaling pathway;>>Endocytosis;>>Morphine addiction
Human protein sequence Database
P43250
Mouse protein sequence database
O70293
Rat protein sequence database
P97711
Cellular localization
Membrane; Lipid-anchor.
Tissue expression
Widely expressed.
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