Immunogen
The antiserum was produced against synthesized peptide derived from human MAP3K6. AA range:281-330
Specificity
MEK Kinase-6 Polyclonal Antibody detects endogenous levels of MEK Kinase-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
Protein name
Mitogen-activated protein kinase kinase kinase 6
Abbreviation
MEK Kinase-6
Other name
MAP3K6; ASK2; MAPKKK6; MEKK6; Mitogen-activated protein kinase kinase kinase 6; Apoptosis signal-regulating kinase 2
Fields
>>MAPK signaling pathway
Human protein sequence Database
O95382
Mouse protein sequence database
Q9WTR2
Rat protein sequence database
Cellular localization
intracellular,
Tissue expression
Brain,PCR rescued clones,Skin,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车