Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human YOD1. AA range:116-165
Specificity
OTUD2 Polyclonal Antibody detects endogenous levels of OTUD2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
Function
function:Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.,sequence caution:Wrong choice of frame.,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 OTU domain.,
Protein name
Ubiquitin thioesterase OTU1
Other name
YOD1; DUBA8; HIN7; OTUD2; Ubiquitin thioesterase OTU1; DUBA-8; HIV-1-induced protease 7; HIN-7; HsHIN7; OTU domain-containing protein 2
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q5VVQ6
Mouse protein sequence database
Q8CB27
Rat protein sequence database
Cellular localization
Cytoplasm . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. .
Tissue expression
Fetal liver,Spinal cord,Testis,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车