Molecular weight (DA)
58kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PFKFB1. AA range:406-455
Specificity
PFK-2 liv Polyclonal Antibody detects endogenous levels of PFK-2 liv protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],
Function
catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in inhibition of the kinase activity.,function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Liver.,
Protein name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Other name
PFKFB1; F6PK; PFRX; 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase liver isozyme
Fields
>>Fructose and mannose metabolism;>>Metabolic pathways;>>AMPK signaling pathway;>>Glucagon signaling pathway
Human protein sequence Database
P16118
Mouse protein sequence database
P70266
Rat protein sequence database
P07953
Cellular localization
cytosol,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex,
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