Immunogen
Synthesized peptide derived from the C-terminal region of human Pim-2.
Specificity
Pim-2 Polyclonal Antibody detects endogenous levels of Pim-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells.,
Protein name
Serine/threonine-protein kinase pim-2
Other name
PIM2; Serine/threonine-protein kinase pim-2; Pim-2h
Fields
>>Pathways in cancer;>>Acute myeloid leukemia
Human protein sequence Database
Q9P1W9
Mouse protein sequence database
Q62070
Rat protein sequence database
Cellular localization
cytoplasm,
Tissue expression
Highly expressed in hematopoietic tissues, in leukemic and lymphoma cell lines, testis, small intestine, colon and colorectal adenocarcinoma cells. Weakly expressed in normal liver, but highly expressed in hepatocellular carcinoma tissues.
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