Molecular weight (DA)
80kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGEF7. AA range:311-360
Specificity
PIXβ Polyclonal Antibody detects endogenous levels of PIXβ protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016],
Function
function:Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with ITCH (By similarity). Interacts with unphosphorylated PAK1.,
Protein name
Rho guanine nucleotide exchange factor 7
Other name
ARHGEF7; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB; Nbla10314; Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85
Fields
>>Regulation of actin cytoskeleton;>>Yersinia infection
Human protein sequence Database
Q14155
Mouse protein sequence database
Q9ES28
Rat protein sequence database
O55043
Cellular localization
Cell junction, focal adhesion . Cell projection, ruffle . Cytoplasm, cell cortex . Cell projection, lamellipodium . Detected at cell adhesions. A small proportion is detected at focal adhesions.
Tissue expression
Amygdala,Bone marrow,Brain,Epithelium,Neuroblastoma,Testis,
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