Molecular weight (DA)
111kD
Immunogen
The antiserum was produced against synthesized peptide derived from human PTPRN2. AA range:206-255
Specificity
PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
Function
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM).,domain:The cytoplasmic domain appears to contain the autoantigenic epitopes.,function:Implicated in development of nervous system and pancreatic endocrine cells.,PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.,
Protein name
Receptor-type tyrosine-protein phosphatase N2
Other name
PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin
Fields
>>Type I diabetes mellitus
Human protein sequence Database
Q92932
Mouse protein sequence database
P80560
Rat protein sequence database
Q63475
Cellular localization
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). .; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane .
Tissue expression
Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755).
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