Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human VRK2. AA range:171-220
Specificity
VRK2 Polyclonal Antibody detects endogenous levels of VRK2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
vaccinia related kinase 2(VRK2) Homo sapiens This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Probable serine/threonine kinase.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.,
Protein name
Serine/threonine-protein kinase VRK2
Other name
VRK2; Serine/threonine-protein kinase VRK2; Vaccinia-related kinase 2
Human protein sequence Database
Q86Y07
Mouse protein sequence database
Q8BN21
Rat protein sequence database
Cellular localization
[Isoform 1]: Cytoplasm . Endoplasmic reticulum membrane ; Single-pass type IV membrane protein . Mitochondrion membrane ; Single-pass type IV membrane protein . Nucleus envelope .; [Isoform 2]: Cytoplasm . Nucleus .
Tissue expression
Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis.
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