Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human WEE2. AA range:151-200
Specificity
Wee 2 Polyclonal Antibody detects endogenous levels of Wee 2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
Function
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
Protein name
Wee1-like protein kinase 2
Other name
WEE2; WEE1B; Wee1-like protein kinase 2; Wee1-like protein kinase 1B; Wee1B kinase
Fields
>>Cell cycle;>>Human immunodeficiency virus 1 infection
Human protein sequence Database
P0C1S8
Mouse protein sequence database
Q66JT0
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659).
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