Molecular weight (DA)
69kD
Immunogen
Synthesized peptide derived from human MyoD (Acetyl Lys99/K102)
Specificity
This antibody detects endogenous levels of Human MyoD (Acetyl Lys99/K102)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],
Function
function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,
Gene Name
MYOD1 BHLHC1 MYF3 MYOD
Protein name
MyoD (Acetyl Lys99/K102)
Other name
Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1;bHLHc1;Myogenic factor 3;Myf-3)
Fields
>>Spinocerebellar ataxia
Human protein sequence Database
P15172
Mouse protein sequence database
P10085
Rat protein sequence database
Q02346
Cellular localization
Nucleus.
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