Immunogen
Synthesized peptide derived from human KSP-Cadherin
Specificity
This antibody detects endogenous levels of KSP-Cadherin at Human
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.05% sodium azide.
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011],
Function
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 6 cadherin domains.,tissue specificity:Kidney specific.,
Gene Name
CDH16 UNQ695/PRO1340
Protein name
KSP-Cadherin
Abbreviation
KSP-Cadherin
Other name
Cadherin-16 (Kidney-specific cadherin;Ksp-cadherin)
Human protein sequence Database
O75309
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Kidney specific.
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