Immunogen
Synthesized peptide derived from human INI-1
Specificity
The antibody can specifically recognize human INI-1 protein, including INI-1A and INI-1B. In western blotting of Hela and LnCap cell lysates, the antibody can label two bands with molecular weight of
Source
Monoclonal Mouse IgG2b, kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,WB: 500-1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015],
Function
disease:Defects in SMARCB1 are a cause of rhabdoid tumor (RDT) [MIM:609322]; also called malignant rhabdoid tumor (MRT). Tumor suppressor. Inactivated in rhabdoid tumors. Rhabdoid tumors are a highly malignant group of neoplasms that usually occur in early childhood. SMARCB1/INI1 is also frequently inactivated in epithelioid sarcomas.,disease:Defects in SMARCB1 are a cause of schwannomatosis [MIM:162091]; also called congenital cutaneous neurilemmomatosis. Schwannomas are benign tumors of the peripheral nerve sheath that usually occur singly in otherwise normal individuals. Multiple schwannomas in the same individual suggest an underlying tumor-predisposition syndrome. The most common such syndrome is NF2. The hallmark of NF2 is the development of bilateral vestibular-nerve schwannomas; but two-thirds or more of all NF2-affected individuals develop schwannomas in other locations, and der
Gene Name
SMARCB1 BAF47 INI1 SNF5L1
Protein name
BAF47;BRG1-associated factor 47;hSNF5;INI1;Integrase interactor 1 protein;Malignant rhabdoid tumor suppressor;RDT;RTPS1;Sfh1p;SMARCB1;SNF5 homolog;SNF5_HUMAN;SNF5L1;Snr1;Sucrose nonfermenting yeast ho
Other name
BAF47;BRG1-associated factor 47;hSNF5;INI1;Integrase interactor 1 protein;Malignant rhabdoid tumor suppressor;RDT;RTPS1;Sfh1p;SMARCB1;SNF5 homolog;SNF5_HUMAN;SNF5L1;Snr1;Sucrose nonfermenting yeast homolog like 1;SWI/SNF complex component SNF5;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI10;Transcription factor TYE4;Transcription regulatory protein SNF5;TYE4
Fields
>>Viral life cycle - HIV-1;>>Thermogenesis;>>Hepatocellular carcinoma
Human protein sequence Database
Q12824
Mouse protein sequence database
Q9Z0H3
Rat protein sequence database
Cellular localization
Nuclear
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