Immunogen
Synthesized peptide derived from human TRAP
Specificity
The antibody can specifically recognize human TRAP protein.
Source
Monoclonal Mouse IgG2a, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008],
Function
catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 2 iron ions per subunit.,disease:This relatively minor intracellular isozyme of acid phosphatase can become the dominant isozyme in certain pathological states (Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias).,similarity:Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.,subunit:Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).,
Protein name
Type 5 acid phosphatase;Acid phosphatase 5 tartrate resistant;Acid phosphatase 5, tartrate resistant;ACP5;EC 3.1.3.2;MGC117378;PPA5_HUMAN;serum band 5 tartrate-resistant acid phosphatase;SPENCDI;T5ap;
Other name
Type 5 acid phosphatase;Acid phosphatase 5 tartrate resistant;Acid phosphatase 5, tartrate resistant;ACP5;EC 3.1.3.2;MGC117378;PPA5_HUMAN;serum band 5 tartrate-resistant acid phosphatase;SPENCDI;T5ap;Tartrate resistant acid ATPase;Tartrate resistant acid phosphatase type 5;Tartrate resistant acid phosphatase type 5 precursor;Tartrate-resistant acid ATPase;Tartrate-resistant acid phosphatase type 5;TR AP;TR-AP;TRACP 5;TRAP;TrATPase;Type 5 acid phosphatase
Fields
>>Riboflavin metabolism;>>Metabolic pathways;>>Lysosome;>>Osteoclast differentiation;>>Rheumatoid arthritis
Human protein sequence Database
P13686
Mouse protein sequence database
Q05117
Rat protein sequence database
P29288
Cellular localization
Cytoplasmic
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