Immunogen
Synthesized peptide derived from human SALL4
Specificity
This antibody detects endogenous levels of human Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommend
Source
Mouse, Monoclonal/IgG2b, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500，WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes a zinc finger transcription factor thought to play a role in the development of abducens motor neurons. Defects in this gene are a cause of Duane-radial ray syndrome (DRRS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
Function
disease:Defects in SALL4 are the cause of Duane-radial ray syndrome (DRRS) [MIM:607323]; also known as Okihiro syndrome. DRRS is a disorder characterized by the association of forearm malformations with Duane retraction syndrome.,disease:Defects in SALL4 are the cause of IVIC syndrome [MIM:147750]. IVIC syndrome is an autosomal dominant condition characterized by upper limbs anomalies (radial ray defects, carpal bones fusion), extraocular motor disturbances, congenital bilateral non-progressive mixed hearing loss. Other less consistent malformations include heart involvement, mild thrombocytopenia and leukocytosis (before age 50), shoulder girdle hypoplasia, imperforate anus, kidney malrotation or rectovaginal fistula. The IVIC syndrome is an allelic disorder of Duane-radial ray syndrome (DRRS) with a similar phenotype.,function:Probable transcription factor.,similarity:Belongs to the sa
Protein name
Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)
Human protein sequence Database
Q9UJQ4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Expressed in testis. Constitutively expressed in acute myeloid leukemia (AML).
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