Immunogen
Synthesized peptide derived from human Glycophorin A，CD235a
Specificity
This antibody detects endogenous levels of human Glycophorin A，CD235a. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH9.0 was highly recommended as antigen repair method in paraffin section
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008],
Function
function:Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus.,online information:Blood group antigen gene mutation database,polymorphism:Along with GYPB, GYPA is responsible for the MNS blood group system.,similarity:Belongs to the glycophorin A family.,
Protein name
Glycophorin A，CD235a
Abbreviation
Glycophorin A
Other name
Glycophorin-A (MN sialoglycoprotein;PAS-2;Sialoglycoprotein alpha;CD antigen CD235a)
Fields
>>Hematopoietic cell lineage;>>Malaria
Human protein sequence Database
P02724
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Appears to be colocalized with SLC4A1.
Tissue expression
Blood,Bone marrow,Kidney,Liver,Lung,Miltenberger class V,
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