Immunogen
Synthesized peptide derived from human MutS Protein Homolog 2(MSH2)
Specificity
This antibody detects endogenous levels of MutS Protein Homolog 2(MSH2) at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:1500. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from Cell supernatant by affinity-chromatography using specific immunogen.
Function
disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal
Protein name
MutS Protein Homolog 2(MSH2)
Other name
DNA mismatch repair protein Msh2 (hMSH2;MutS protein homolog 2)
Fields
>>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer
Human protein sequence Database
P43246
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus . Chromosome .
Tissue expression
Ubiquitously expressed.
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