Immunogen
Synthesized peptide derived from human Cytokeratin Pan
Specificity
The antibody can recognize multiple human Cytokeratins, including CK10, 13, 14, 15, 16, 18, 19, and it can be used for immunohistochemical detection of tumors from monolayer and multilayered epithel
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.94% sodium azide.
Dilution rate
IHC-p 1:100-500, WB 1:200-1000, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Protein name
Cytokeratin Pan
Abbreviation
Cytokeratin Pan
Fields
>>Rap1 signaling pathway;>>Apelin signaling pathway;>>Hippo signaling pathway;>>Cell adhesion molecules;>>Adherens junction;>>Bacterial invasion of epithelial cells;>>Pathways in cancer;>>Endometrial cancer;>>Thyroid cancer;>>Melanoma;>>Bladder cancer;>>Gastric cancer
Human protein sequence Database
P12830/P19022/P22223/P55283/O75309
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell junction, adherens junction . Cell membrane ; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue expression
Non-neural epithelial tissues.
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