Immunogen
Synthesized peptide derived from human TRAP
Specificity
The antibody can specifically recognize human TRAP protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.97% sodium azide.
Dilution rate
IHC-p 1:100-500, IF 1:100-500
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate. [provided by RefSeq, Aug 2008],
Function
catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 2 iron ions per subunit.,disease:This relatively minor intracellular isozyme of acid phosphatase can become the dominant isozyme in certain pathological states (Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias).,similarity:Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.,subunit:Exists either as monomer or, after proteolytic processing, as a dimer of two chains linked by disulfide bond(s).,
Other name
Tartrate-resistant acid phosphatase type 5 (TR-AP;EC 3.1.3.2;Tartrate-resistant acid ATPase;TrATPase;Type 5 acid phosphatase)
Fields
>>Riboflavin metabolism;>>Metabolic pathways;>>Lysosome;>>Osteoclast differentiation;>>Rheumatoid arthritis
Human protein sequence Database
P13686
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Lysosome.
Tissue expression
Cytoplasmic
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