Immunogen
Synthesized peptide derived from human Tyrosinase
Specificity
The antibody can specifically recognize human Tyrosinase protein.
Source
Mouse, Monoclonal/IgG1, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
tyrosinase(TYR) Homo sapiens The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008],
Function
catalytic activity:L-tyrosine + L-dopa + O(2) = L-dopa + dopaquinone + H(2)O.,cofactor:Binds 2 copper ions per subunit.,disease:Defects in TYR are the cause of oculocutaneous albinism type I temperature-sensitive (OCA-ITS) [MIM:606952]. OCA-ITS patients have white axillary and scalp hair and pigmented arm and leg hair.,disease:Defects in TYR are the cause of oculocutaneous albinism type IA (OCA-IA) [MIM:203100]. OCA-I, also known as tyrosinase negative oculocutaneous albinism, is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes. OCA-I is divided into 2 types: type IA, characterized by complete lack of tyrosinase activity due to production of an inactive enzyme, and type IB characterized by reduced activity of tyrosinase. OCA-IA patients presents with the life-long absence of melanin pigment after birth and manifest increased sensitivity to ultrav
Protein name
ATN;CMM8;LB24 AB;LB24-AB;Monophenol monooxygenase;OCA1;OCA1A;OCAIA;Oculocutaneous albinism IA;SHEP3;SK29 AB;SK29-AB;Tumor rejection antigen AB;TYR;TYRO_HUMAN;tyrosinase (oculocutaneous albinism IA);Ty
Other name
ATN;CMM8;LB24 AB;LB24-AB;Monophenol monooxygenase;OCA1;OCA1A;OCAIA;Oculocutaneous albinism IA;SHEP3;SK29 AB;SK29-AB;Tumor rejection antigen AB;TYR;TYRO_HUMAN;tyrosinase (oculocutaneous albinism IA);Tyrosinase
Fields
>>Tyrosine metabolism;>>Metabolic pathways;>>Melanogenesis
Human protein sequence Database
P14679
Mouse protein sequence database
P11344
Rat protein sequence database
Cellular localization
Cytoplasmic
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