Immunogen
Synthesized peptide derived from human hCG α
Specificity
The antibody can specifically recognize α subunits of human CG, LH, FSH and TSH proteins.
Source
Monoclonal Mouse IgG3, Kappa
Formulation
PBS, pH7.2, 0.03% Porcolin 300, containing stabilizing protein
Dilution rate
IHC-p 1:200-400,
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
Function
online information:Proteic grace - Issue 77 of December 2006,similarity:Belongs to the glycoprotein hormones subunit alpha family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
Protein name
Anterior pituitary glycoprotein hormones common subunit alpha;CG alpha;CG-alpha;cga;Choriogonadotropin alpha chain;Chorionic Gonadotrophin Alpha;Chorionic Gonadotrophin Alpha Subunit;Chorionic gonadot
Other name
Anterior pituitary glycoprotein hormones common subunit alpha;CG alpha;CG-alpha;cga;Choriogonadotropin alpha chain;Chorionic Gonadotrophin Alpha;Chorionic Gonadotrophin Alpha Subunit;Chorionic gonadotrophin subunit alpha;chorionic gonadotropin, alpha polypeptide;Follicle-stimulating hormone alpha;Follicle-stimulating hormone alpha chain;follicle-stimulating hormone alpha subunit;Follitropin alpha;Follitropin alpha chain;FSH Alpha;FSH-alpha;FSHA;GLHA_HUMAN;Glycoprotein hormones alpha chain;Glycoprotein Hormones Alpha Polypeptide;GPH Alpha;GPHa;GPHA1;HCG;hyrotropin alpha;LH-alpha;LHA;LSH alpha;LSH-alpha;Luteinizing hormone alpha;Luteinizing hormone alpha chain;Lutropin alpha;Lutropin alpha chain;Thyroid Stimulating Hormone Alpha;Thyroid Stimulating Hormone Alpha Chain;Thyroid-stimulating hormone alpha chain;Thyrotropin alpha chain;TSH Alpha;TSH-alpha;TSHA
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>GnRH signaling pathway;>>Ovarian steroidogenesis;>>Prolactin signaling pathway;>>Thyroid hormone synthesis;>>Regulation of lipolysis in adipocytes;>>GnRH secretion;>>Autoimmune thyroid disease
Human protein sequence Database
P01215
Mouse protein sequence database
P01216
Rat protein sequence database
P11962
Cellular localization
Cytoplasmic
Tissue expression
Placenta/ Pituitary
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