Molecular weight (DA)
174kD
Immunogen
Synthesized peptide derived from human TOP2A (Phospho Ser1213)
Specificity
This antibody detects endogenous levels of Human TOP2A (Phospho Ser1213)
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5.,
Function
DNA metabolic process, DNA replication, DNA topological change, DNA ligation, DNA repair, DNA packaging, apoptosis,response to DNA damage stimulus, nucleus organization, chromosome segregation, intracellular signaling cascade, cell death, regulation of cell death, positive regulation of cell death, programmed cell death, death, second-messenger-mediated signaling, chromosome condensation, apoptotic nuclear changes, apoptotic chromosome condensation,cellular response to stress, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of viral genome replication, positive regulation of viral genome replication, regulation of retroviral genome replication, positive regulation of retroviral genome replication,phosphoinositide-mediated signaling, positive regulation of viral reproduction, regulatio
Protein name
TOP2A (Phospho Ser1213)
Other name
DNA topoisomerase 2-alpha (EC 5.99.1.3;DNA topoisomerase II, alpha isozyme)
Fields
>>Platinum drug resistance
Human protein sequence Database
P11388
Mouse protein sequence database
Q01320
Rat protein sequence database
P41516
Cellular localization
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .
Tissue expression
Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056).
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