Molecular weight (DA)
89kD
Immunogen
Synthetic Peptide of 42644
Specificity
The antibody detects endogenous Oct1 protein.
Formulation
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Dilution rate
WB: 1:500-2000 IF 1:200 IHC 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Background
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010],
Function
function:Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.,PTM:Phosphorylated by PRKDC.,similarity:Belongs to the POU transcription factor family. Class-2 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,subunit:Interacts with NR3C1, AR, PGR and HCFC1.,tissue specificity:Ubiquitous. Isoform 2 is lymphocyte-specific.,
Protein name
POU domain class 2 transcription factor
Fields
>>Herpes simplex virus 1 infection;>>Lipid and atherosclerosis
Human protein sequence Database
P14859/P09086
Mouse gene ID
18986/18987
Mouse protein sequence database
Rat protein sequence database
P31503
Cellular localization
Nucleus.
Tissue expression
Ubiquitous. Isoform 2 is lymphocyte-specific.
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