Molecular weight (DA)
35kD
Immunogen
The antiserum was produced against synthesized peptide derived from human POU4F3. AA range:231-280
Specificity
Brn-3 Polyclonal Antibody detects endogenous levels of Brn-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009],
Function
disease:Defects in POU4F3 are the cause of non-syndromic sensorineural deafness autosomal dominant type 15 (DFNA15) [MIM:602459]. DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:May play a role in determining or maintaining the identities of a small subset of visual system neurons.,online information:Gene page,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina.,
Protein name
POU domain class 4 transcription factor 3
Other name
POU4F3; BRN3C; POU domain; class 4, transcription factor 3; Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C
Human protein sequence Database
Q15319
Mouse protein sequence database
Q63955
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Preferentially localized in the nucleus. .
Tissue expression
Brain. Seems to be specific to the retina.
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