Molecular weight (DA)
42kD
Immunogen
The antiserum was produced against synthesized peptide derived from human POU4F1. AA range:311-360
Specificity
Brn-3a Polyclonal Antibody detects endogenous levels of Brn-3a protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012],
Function
developmental stage:Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth.,function:Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye.,
Protein name
POU domain class 4 transcription factor 1
Other name
POU4F1; BRN3A; RDC1; POU domain; class 4, transcription factor 1; Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1
Human protein sequence Database
Q01851
Mouse protein sequence database
P17208
Rat protein sequence database
P20266
Cellular localization
Nucleus . Cytoplasm .
Tissue expression
Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.
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