Immunogen
The antiserum was produced against synthesized peptide derived from human EMX2. AA range:91-140
Specificity
Emx2 Polyclonal Antibody detects endogenous levels of Emx2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Se
Function
disease:Defects in EMX2 are the cause of schizencephaly [MIM:269160]. Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro-spinal fluid.,function:Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.,similarity:Belongs to the EMX homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Cerebral cortex.,
Protein name
Homeobox protein EMX2
Other name
EMX2; Homeobox protein EMX2; Empty spiracles homolog 2; Empty spiracles-like protein 2
Human protein sequence Database
Q04743
Mouse protein sequence database
Q04744
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Cerebral cortex.
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