Immunogen
The antiserum was produced against synthesized peptide derived from human HOXA1/B1/D1. AA range:216-265
Specificity
Hox-A1/B1/D1 Polyclonal Antibody detects endogenous levels of Hox-A1/B1/D1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008],
Function
function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.,polymorphism:The two common alleles; HOX1B*A and HOX1B*B have a frequency of 78.8% and 21.2% respectively.,similarity:Belongs to the Antp homeobox family. Labial subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,
Protein name
Homeobox protein Hox-B1
Abbreviation
Hox-A1/B1/D1
Other name
HOXB1; HOX2I; Homeobox protein Hox-B1; Homeobox protein Hox-2I; HOXA1; HOX1F; Homeobox protein Hox-A1; Homeobox protein Hox-1F; HOXD1; HOX4; HOX4G; Homeobox protein Hox-D1; Homeobox protein Hox-GG
Fields
>>Signaling pathways regulating pluripotency of stem cells
Human gene ID
3211/3198/3231
Human protein sequence Database
P14653/P49639/Q9GZZ0
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
PCR rescued clones,
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