Molecular weight (DA)
34kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HoxB4. AA range:86-135
Specificity
HoxB4 Polyclonal Antibody detects endogenous levels of HoxB4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed in whole embryos and fetuses at 5-9 weeks from conception.,function:Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.,similarity:Belongs to the Antp homeobox family. Deformed subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,
Protein name
Homeobox protein Hox-B4
Other name
HOXB4; HOX2F; Homeobox protein Hox-B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F
Human protein sequence Database
P17483
Mouse protein sequence database
P10284
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Placenta,Testis,Uterus,
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