Immunogen
Synthesized peptide derived from Nkx-6.1 . at AA range: 180-260
Specificity
Nkx-6.1 Polyclonal Antibody detects endogenous levels of Nkx-6.1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008],
Function
function:May be important for control of islet development and/or regulation of insulin biosynthesis.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Pancreatic beta cells.,
Protein name
Homeobox protein Nkx-6.1
Other name
NKX6-1; NKX6A; Homeobox protein Nkx-6.1; Homeobox protein NK-6 homolog A
Fields
>>Maturity onset diabetes of the young
Human protein sequence Database
P78426
Mouse protein sequence database
Q99MA9
Rat protein sequence database
O35762
Cellular localization
Nucleus .
Tissue expression
Pancreatic beta cells.
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