Immunogen
Purified recombinant fragment of human Cerberus expressed in E. Coli.
Specificity
Cerberus Monoclonal Antibody detects endogenous levels of Cerberus protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008],
Function
function:Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.,PTM:N-glycosylated.,sequence caution:Translated as Ser.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,subunit:Forms monomers and predominantly dimers.,
Other name
CER1; DAND4; Cerberus; Cerberus-related protein; DAN domain family member 4
Fields
>>Wnt signaling pathway
Human protein sequence Database
O95813
Mouse protein sequence database
O55233
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Blood,PCR rescued clones,
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