Immunogen
Purified recombinant fragment of human EPO expressed in E. Coli.
Specificity
EPO Monoclonal Antibody detects endogenous levels of EPO protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008],
Function
disease:Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2) [MIM:612623]; also called susceptibility to proliferative diabetic retinopathy (PDR) or susceptbility to diabetic end-stage renal disease (ESRD). Significant morbidity and mortality among patients with diabetes mellitus result largely from a greatly increased incidence of microvascular complications. PDR and ESRD are two of the most common and severe microvascular complications of diabetes. A high concordance exists in the development of PDR and ESRD in diabetic patients, as well as strong familial aggregation of these complications, suggesting a common underlying genetic mechanism. EPO is a potent angiogenic factor observed in the diabetic human and mouse eye.,function:Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation
Protein name
Erythropoietin
Other name
EPO; Erythropoietin; Epoetin
Fields
>>Cytokine-cytokine receptor interaction;>>HIF-1 signaling pathway;>>PI3K-Akt signaling pathway;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Pathways in cancer
Human protein sequence Database
P01588
Mouse protein sequence database
P07321
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals.
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