Immunogen
Purified recombinant fragment of GDF-8 expressed in E. Coli.
Specificity
GDF-8 Monoclonal Antibody detects endogenous levels of GDF-8 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
myostatin(MSTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016],
Function
function:Acts specifically as a negative regulator of skeletal muscle growth.,online information:Myostatin entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity.,
Protein name
Growth/differentiation factor 8
Other name
MSTN; GDF8; Growth/differentiation factor 8; GDF-8; Myostatin
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
O14793
Mouse protein sequence database
O08689
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Colon,Muscle,Pericardium,Skeletal muscle,
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