Immunogen
Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Specificity
MCP-1 Monoclonal Antibody detects endogenous levels of MCP-1 protein.
Formulation
Purified antibody in PBS containing 0.03% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013],
Function
function:Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.,online information:CCL2 entry,polymorphism:Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility [MIM:607948].,PTM:Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial
Protein name
C-C motif chemokine 2
Other name
CCL2; MCP1; SCYA2; C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic protein 1; MCP-1; Monocyte secretory protein JE; Small-inducible cytokine A2
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>AGE-RAGE signaling pathway in diabetic complications;>>Yersinia infection;>>Chagas disease;>>Malaria;>>Human cytomegalovirus infection;>>Influenza A;>>Herpes simplex virus 1 infection;>>Coronavirus disease - COVID-19;>>Rheumatoid arthritis;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
Human protein sequence Database
P13500
Mouse protein sequence database
P10148
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level) (PubMed:23765988). Expressed in monocytes (PubMed:2513477).
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