Molecular weight (DA)
20kD
Immunogen
Purified recombinant human IL8 protein fragments expressed in E.coli.
Specificity
This antibody detects over-expressed and recombinant levels of IL8 and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008],
Function
function:IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.,online information:Interleukin-8 entry,PTM:Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homodimer.,
Other name
(Ala-IL-8)77;(Ser-IL-8)72;3 10C;310C;AMCF 1;AMCF1;b ENAP;Bbeta thromboglobulin like protein;Beta thromboglobulin like protein;C-X-C motif chemokine 8;CXC chemokine ligand 8;CXCL 8;CXCL8;Emoctakin;GCP 1;GCP-1;GCP/IL-8 protein I;GCP/IL-8 protein II;GCP/IL-8 protein III;GCP/IL-8 protein IV;GCP/IL-8 protein V;GCP/IL-8 protein VI;GCP1; Granulocyte chemotactic protein 1;IL 8;IL-8;IL-8(1-77);IL-8(9-77);IL8;IL8/NAP1 form I;IL8/NAP1 form II;IL8/NAP1 form III;IL8/NAP1 form IV;IL8/NAP1 form V;IL8/NAP1 form VI;IL8_HUMAN; Inteleukin 8;Interleukin8;K 60;K60;LECT;LUCT; Lymphocyte derived neutrophil activating factor;Lymphocyte-derived neutrophil-activating factor;LYNAP;MDNCF;MDNCF-b;MDNCF-c; MONAP;Monocyte derived neutrophil activating peptide;Monocyte derived neutrophil activating protein; Monocyte derived neutrophil chemotactic factor;Monocyte-derived neutrophil chemotactic factor;Monocyte-derived neutrophil-activating peptide;NAF;NAP 1; NAP-1;NAP1;Neutrophil activating factor;Neutrophil activating
Fields
>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>Chemokine signaling pathway;>>NF-kappa B signaling pathway;>>Phospholipase D signaling pathway;>>Cellular senescence;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>IL-17 signaling pathway;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Alcoholic liver disease;>>Epithelial cell signaling in Helicobacter pylori infection;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Yersinia infection;>>Chagas disease;>>Malaria;>>Amoebiasis;>>Hepatitis B;>>Human cytomegalovirus infection;>>Influenza A;>>Kaposi sarcoma-associated herpesvirus infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Bladder cancer;>>Rheumatoid arthritis;>>Lipid and atherosclerosis
Human protein sequence Database
P10145
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Chronic myeloid leukemia cell,Kidney,Lung,Lung carcinoma,Neutrophil,Periphe
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